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Pure hypercholesterolemia: Causes, symptoms, and treatment.
Two forms of the condition exist: heterozygous familial hypercholesterolemia HeFH and homozygous familial hypercholesterolemia HoFH. The HeFH condition occurs when a person inherits pure hypercholesterolemia from one parent. The HoFH condition occurs when a person inherits pure hypercholesterolemia from both parents.
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Hypercholesterolemia Symptoms, diagnosis and treatment BMJ Best Practice US.
Hypercholesterolemia is treated with lifestyle modifications such as dietary changes, exercise, and smoking cessation, as well as pharmacologic intervention with statin therapy, and selective use of the cholesterol absorption inhibitor ezetimibe or a proprotein convertase subtilisin/kexin type 9 PCSK9 inhibitor.
Clinical Genetic Testing for Familial Hypercholesterolemia JACC: Journal of the American College of Cardiology.
Conversely, high-risk patients may meet criteria for a clinical diagnosis of FH high LDL-C level and positive family history of hypercholesterolemia and premature CAD but may have negative FH genetic test results potentially due to other, undefined genetic causes of high LDL-C levels.
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Hypercholesterolemia Genetics Home Reference NIH.
Less commonly, hypercholesterolemia can be caused by mutations in the APOB, LDLRAP1, or PCSK9 gene. Changes in the APOB gene result in a form of inherited hypercholesterolemia known as familial defective apolipoprotein B-100 FDB. LDLRAP1 mutations are responsible for another type of inherited high cholesterol, autosomal recessive hypercholesterolemia ARH.
Familial Hypercholesterolemia FH American Heart Association.
Podcast When high cholesterol and heart disease runs in the family: Familial Hypercholesterolemia FH. Podcast Managing Familial Hypercholesterolemia FH. Podcast Women and Familial Hypercholesterolemia. Podcast Children and Familial Hypercholesterolemia. How To Get Your Cholesterol Tested. Podcast When high cholesterol and heart disease runs in the family: Familial Hypercholesterolemia FH.
What is Hypercholesterolemia?
Hypercholesterolemia does not usually present with any symptoms and the only way to check for the condition is to perform a check of the blood cholesterol level, referred to as a lipid profile. This test typically includes a check of the total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride level.
Types of Hypercholesterolemia Medications You Should Know.
Familial hypercholesterolemia runs in families, regardless of how healthy a persons diet or exercise habits may be. Fortunately, there are hypercholesterolemia medications for individuals whose cholesterol levels remain high even with healthy lifestyle habits. Here are a few you should know about.
Familial hypercholesterolemia Symptoms and causes Mayo Clinic.
Familial hypercholesterolemia affects the way the body processes cholesterol. As a result, people with familial hypercholesterolemia have a higher risk of heart disease and a greater risk of early heart attack. The gene that causes familial hypercholesterolemia is inherited. The condition is present from birth.
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