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Hypericin C30H16O8 PubChem.
National Library of Medicine NCBI National Center for Biotechnology Information. OPEN CHEMISTRY DATABASE. This application requires Javascript. Please turn on Javascript in order to use this application. Data Citation Guidelines. National Center for Biotechnology Information, U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.
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Hypericin C30H16O8 ChemSpider.
Hypericin from Hype ricum perforatumCy clo-Werrol; Hyperic um red. InChI1/C30H16O8/c1 7-3-93119-23-15 716-824-103220 241628-26-1812 346-1436222630 203817-11335-1 3352129193725 17272328/h3-63, 1-36H1-2H., Phenanthro11098, opqraperylene-71, 4-dione134681, 3-hexahydroxy-1011, dimethyl, stereoi somer. johns wort extr act, 41, powder. Validated by Experts, Validated by Users, Non-Validated, Removed by Users Edit.
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Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's' Wort Plant, in Patients with Chronic Hepatitis C Virus Infection Antimicrobial Agents and Chemotherapy.
The first 12 patients enrolled in the study were to receive an 8-week course of 0.05 mg of hypericin per kg of body weight in liquid form orally once a day the study medication was kindly provided by VimRx Pharmaceuticals, Wilmington, Del.
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Hypericin Wikipedia.
2 3 Hypericin is believed to act as an antibiotic, antiviral 2 and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine hydroxylase, leading to increased dopamine levels, citation needed although thus possibly decreasing norepinephrine and epinephrine.
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Weekly Dose: St John's' Wort, the flower that can treat depression.
It has become more common for complementary medicine manufacturers to include a standardised amount of the herb constituents on the label. The daily dose range for total hypericin content is 0.75mg to 2.7mg of hypericin daily. The published studies generally used standardised extracts to contain 0.3% hypericin and 2-5% hyperforin.
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Hypericin an overview ScienceDirect Topics. ScienceDirect.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
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Frontiers Hypericin in the Light and in the Dark: Two Sides of the Same Coin Plant Science.
The instilled hypericin accumulated selectively in the bladder urothelial tumors and the normal urothelium in a ratio of 121, but no hypericin was detected in normal bladder submucosa and muscle layers, which is an important factor to avoid underlying tissue damage.
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Hypericin-the facts about a controversial agent. PubMed NCBI.
Recent studies report antidepressive, antineoplastic, antitumor and antiviral human immunodeficiency and hepatitis C virus activities of hypericin; intriguing information even if confirmation of data is incomplete and mechanisms of these activities still remain largely unexplained. In other contemporary studies, screening hypericin for inhibitory effects on various pharmaceutically important enzymes such as MAO monoaminoxidase, PKC protein kinase C, dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP cytochrome P450, has yielded results supporting therapeutic potential.
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Hypericin an overview ScienceDirect Topics. ScienceDirect.
However, hypericin is known to induce skin phototoxicity not only after systemic administration but also after topical application, especially when applied as its precursor acetate ester 2833., Therefore, NPs can be used to shield hypericin till the target cells are reached.
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Hypericin Supplier CAS 548-04-9 Tocris Bioscience.
Lenard et al 1993 Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. 90 158 PMID: 7678335. If you know of a relevant reference for Hypericin, please let us know.
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